Research Group Neeße

Pancreatic Ductal Adenocarcinoma - Microbiome As Predictor of Subtypes. Prospective bicentric clinical translational study (University Medical Center Goettingen and Medical School Hannover) to discover microbiome patterns associated with PDA molecular subtypes. (PI: Albrecht Neesse, NCT04922515)

Status:

• Recruitment continuously ongoing
• Analysis for different research questions conducted
• Publications:
  • DOI: 10.1016/j.pan.2023.07.008
  • DOI: 10.1093/bjs/znad129

Prediction of postoperative pancreatic fistula by microbiome. A European-wide multicentre prospective cohort trial in collaboration with the Department of General, Visceral and Paediatric Surgery of the University Medical Center Goettingen (PD Dr. Florian Bösch, Prof. Dr. Michael Ghadimi) to validate microbial classifier for preoperative prediction of postoperative pancreatic fistula (PI: Christoph Ammer-Herrmenau)

Status:

• Submitted ethical approval
• First draft of study protocol
• Writing grant proposal

CAR T cell treatment – Microbiome As Prediction of Side effects. A tricentric clinical translational trial (in cooperation with Inselspital Bern, University Hospital Muenster) explore the usability of the orointestinal microbiome predicting immunological side effects of CAR T cell treatmenmt (Cytokine Releasing Syndrome, Immune effector cell-associated neurotoxicity syndrome) 

Status:

• Recruiting

Microbiome influenced by oatmeal. An exploratory longitudinal trial to analyse the impact on oatmeal diet on microbiome and insulin resistance in patients with type II diabetes.

Status:

• Recruiting

Proton pump inhibitors and stent occlusion rate of lumen apposing metal stents. A European-wide multicentre retrospective cohort trial to elucidate the role of proton pump inhibitors in lumen apposing metal stents related complication. (PI: Christoph Ammer-Herrmenau)

(Mortality And Mortality by microBiome patterns in Acute pancreatitis)

MAMBA is an international longitudinal long-term follow-up study evaluating morbidity and mortality of acute pancreatitis patients that were enrolled in P-MAPS I.

(Post Ercp-pancreatitis - PrEdiction thRough Microbiome in patients with Native Papilla)

PEPERMINT is a mono-centric prospective observational trial evaluating early changes of the oral and rectal microbiome upon post-ERCP pancreatitis.

• Ulrike Wegner (TA)
• Jutta Blumberg (TA)
• Annika Raddatz (TA)
• Areej Shahbaz (PhD Student)
• Johannes Richter (PhD Student)
• Dr. med. Sören Buchholz (Clinician Scientist)
• Dr. med. Mark Weingarten (Clinician Scientist)
• Jacob Hamm (Clinician Scientist)
• Cathleen Heuer (cand. med. - Stipendiatin Promotionskolleg Experimentelle Medizin)
• Lousia Hübner (student. HiWi)
• Catharina Lingens (cand. med.)
• Alexandra Lüers (cand. med.)
• Isabel Toussaint (cand med.)
• Rahel Scholz (cand. med.)
• Richard Meier (cand. med.)
• Charlotte Vogel (cand med.)
• Helena Lescow (cand. med. - Promotionskolleg)
• Louisa Eskelson (cand. med. - Promotionskolleg)
• Dr. rer. nat. Linh Dang (Post-Doc – Bioinformatik)

• Dr. rer. nat. Melanie Patzak
• Dr. rer. nat Iswarya Ramu
• Dr. rer. nat. Nina Pfisterer
• Syeda Shamima Nasrin, B.Sc
• Dr. med. Lukas Klein
• Dr. med. Lisa Knoll
• Dr. med. Bastian Grieme
• Dr. med. Konstantin Heuscher
• Dr. med. Johannes Hofer
• Dr. med. Melissa Porsche
• Dr. med. Charlotte Ratei
• Dr. med. Janina Rühl
• Dr. med. Laurin Wolf

• Prof. Michael Ghadimi, PD. Dr. Florian Bösch (Department of General, Visceral and Pediatric Surgery)
• Dr. Kai Antweiler, Dr. Thomas Asendorf (Department of Medical Statistics)
• Prof. Dr. Karl Toischer (Department of Cardiology and Pneumology)
• Prof. Dr. Michael Zeißberg (Department of Nephrology and Rheumatology)
• Prof. Dr. Philipp Ströbel, Prof. Dr. Argyris Papantonis, Dr. Stephan Küffer (Department of Pathology)
• Prof. Dr. Ulrich Sax (Department of Medical Informatics)

• PD. Dr. Georg Beyer, Prof. Dr. Julia Mayerle, Dr. Simon Sirtl (Department of Medicine II, University Hospital, LMU Munich, Germany)
• Prof. Dr. Gabriele Capurso (Vita-Salute San Raffaele University, Pancreatobiliary Endoscopy and Endosonography Division, Milano, Italy)
• Dr. Julian Cardinal von Widdern, Dr. Marko Damm, Prof. Dr. Jonas Rosendahl (Department of Medicine I, University Hospital Halle, Germany)
• PD Dr. Fabian Frost, PD Dr. Matthias Sendler (Department of Medicine A, University Medicine Greifswald, Germany)
• Dr. Antonio Gomes, Dr. Vito Nunes (Department of General Surgery Hospital Professor Doctor Frenando Fonseca, Amadora, Portugal)
• Dr. Robert Henker, Prof. Dr. Albrecht Hoffmeister (Medical Department II, Division of Gastroenterology, University Hospital of Leipzig, Germany)
• Dr. Christian Meinhardt (Department of Gastroenterology, University Hospital, Klinikum Oldenburg, Germany)
• Dr. Łukasz Nawacki (Collegium Medicum, The Jan Kochanowski University in Kielce, Poland)
• Dr. Arpád Panyko (4th Department of Surgery, University Hospital Bratislava, Slovakia)
• PD Dr. Veit Phillip, PD Dr. Sebastian Rasch (Department of Medicine II, University Hospital rechts der Isar, Technical University Munich, Germany)
• Prof. Dr. Aldis Pukitis, Dr. Diana Riekstina (Pauls Stradins Clinical University Hospital, Riga, Lativia)
• Dr. Ecaterina Rinja, Dr. Sandru Vasile (Department of Gastroenterology, Clinical Emergency Hospital of Bucharest, Romania)
• Prof. Dr. Maria Lourdes Ruiz-Rebollo (Aparato Digestivo, Hospital Clínico Universitario de Valladolid, Spain)
• Prof. Robert Jaster, Dr. Julia Woitalla (Department of Medicine II, University Hospital Rostock)
• Prof. Dr. Steven A Johnson (Robert Bosch center, Stuttgart, Germany)