Research Focus
Our group is interested in inflammatory and malignant gastrointestinal disorders, in particular acute pancreatitis and pancreatic ductal adenocarcinoma. In both disorders inflammatory and neoplastic insults lead to a pronounced activation of the pancreas microenvironment resulting in highly complex transcriptional and biophysical alterations through the activation of a variety of cells such as pancreatic stellate cells, stem cells, inflammatory/immune cells, and a dynamic stromal response. More recently, a pancreas-specific tumor microbiome has been described that may have profound, yet unkowm implications on benign and malignant diseases of the pancreas. The Neesse laboratory aims to investigate this exciting and emerging field in a combined translational and clinical research program. To this end, a broad spectrum of (epi-) genetic, biochemical, transcriptional and 3rd generation sequencing approaches are employed to dissect the distinct roles of the various cell types and their mutual interaction within the pancreas microenvironment during acute pancreatic inflammation and neoplastic transformation. Ultimately, we aim to rapidly translate our findings to novel diagnostic and therapeutic concepts for patients.
Our group has initiated several prospective clinical-translational and one retrospective clinical trials.
Clinical Trials
P-MAPS
Pancreatitis- Microbiome As Predictor of Severity: Prospective multicentre clinical-translational study to discover early microbiome biomarkers that predict severity of acute pancreatitis. (PI: Albrecht Neesse, NCT04777812)
Status:
- Recruitment successfully accomplished
- Analysis conducted
- Publication: DOI: 10.1136/gutjnl-2023-330987
PDA-MAPS
Pancreatic Ductal Adenocarcinoma - Microbiome As Predictor of Subtypes. Prospective bicentric clinical translational study (University Medical Center Goettingen and Medical School Hannover) to discover microbiome patterns associated with PDA molecular subtypes. (PI: Albrecht Neesse, NCT04922515)
Status:
- Recruitment continuously ongoing
- Analysis for different research questions conducted
- Publications:
POPEYE trial
Prediction of postoperative pancreatic fistula by microbiome. A European-wide multicentre prospective cohort trial in collaboration with the Department of General, Visceral and Paediatric Surgery of the University Medical Center Goettingen (PD Dr. Florian Bösch, Prof. Dr. Michael Ghadimi) to validate microbial classifier for preoperative prediction of postoperative pancreatic fistula (PI: Christoph Ammer-Herrmenau)
Status:
- Submitted ethical approval
- First draft of study protocol
- Writing grant proposal
CART-MAPS
CAR T cell treatment – Microbiome As Prediction of Side effects. A tricentric clinical translational trial (in cooperation with Inselspital Bern, University Hospital Muenster) explore the usability of the orointestinal microbiome predicting immunological side effects of CAR T cell treatmenmt (Cytokine Releasing Syndrome, Immune effector cell-associated neurotoxicity syndrome)
Status:
- Recruiting
Publications
Team
Kontaktinformationen
- Telefon: +49 551 3965667
- E-Mail-Adresse: albrecht.neesse(at)med.uni-goettingen.de
Research group leader
Assistenzarzt
Leitung des molekularen Pankreasprogramms (MolPAC)
Antibiotic Stewardship-Experte (ABS-Experte)
MitarbeiterInnen
- Ulrike Wegner (TA)
- Jutta Blumberg (TA)
- Areej Shahbaz (PhD Student)
- Nina Pfisterer (PhD Student)
- Dr. med. Sören Buchholz (Clinician Scientist)
- Dr. med. Mark Weingarten (Clinician Scientist)
- Jacob Hamm (Clinician Scientist)
- David Becker (cand. med.)
- Cathleen Heuer (cand. med. - Stipendiatin Promotionskolleg Experimentelle Medizin)
- Lousia Hübner (student. HiWi)
- Catharina Lingens (cand. med.)
- Alexandra Lüers (cand. med.)
- Charlotte Ratei (cand. med. - KFO5002-Stipendiatin)
- Janina Rühl (cand. med.)
- Isabel Toussaint (cand med.)
- Laurin Wolf (cand. med.)
Alumni
- Dr. rer. nat. Melanie Patzak
- Dr. rer. nat Iswarya Ramu
- Syeda Shamima Nasrin, B.Sc
- Dr. med. Lukas Klein
- Dr. med. Lisa Knoll
- Dr. med. Bastian Grieme
- Dr. med. Johannes Hofer
- Dr. med. Melissa Porsche
- Dr. med. Konstantin Heuscher
UMG-interne Kooperationspartner
- Prof. Michael Ghadimi, PD. Dr. Florian Bösch (Department of General, Visceral and Pediatric Surgery)
- Dr. Kai Antweiler, Dr. Thomas Asendorf (Department of Medical Statistics)
- Prof. Dr. Karl Toischer (Department of Cardiology and Pneumology)
- Prof. Dr. Michael Zeißberg (Department of Nephrology and Rheumatology)
- Prof. Dr. Philipp Ströbel, Prof. Dr. Argyris Papantonis, Dr. Stephan Küffer (Department of Pathology)
- Prof. Dr. Ulrich Sax (Department of Medical Informatics)
UMG-externe Kooperationspartner
- PD. Dr. Georg Beyer, Prof. Dr. Julia Mayerle, Dr. Simon Sirtl (Department of Medicine II, University Hospital, LMU Munich, Germany)
- Prof. Dr. Gabriele Capurso (Vita-Salute San Raffaele University, Pancreatobiliary Endoscopy and Endosonography Division, Milano, Italy)
- Dr. Julian Cardinal von Widdern, Dr. Marko Damm, Prof. Dr. Jonas Rosendahl (Department of Medicine I, University Hospital Halle, Germany)
- PD Dr. Fabian Frost, PD Dr. Matthias Sendler (Department of Medicine A, University Medicine Greifswald, Germany)
- Dr. Antonio Gomes, Dr. Vito Nunes (Department of General Surgery Hospital Professor Doctor Frenando Fonseca, Amadora, Portugal)
- Dr. Robert Henker, Prof. Dr. Albrecht Hoffmeister (Medical Department II, Division of Gastroenterology, University Hospital of Leipzig, Germany)
- Dr. Christian Meinhardt (Department of Gastroenterology, University Hospital, Klinikum Oldenburg, Germany)
- Dr. Łukasz Nawacki (Collegium Medicum, The Jan Kochanowski University in Kielce, Poland)
- Dr. Arpád Panyko (4th Department of Surgery, University Hospital Bratislava, Slovakia)
- PD Dr. Veit Phillip, PD Dr. Sebastian Rasch (Department of Medicine II, University Hospital rechts der Isar, Technical University Munich, Germany)
- Prof. Dr. Aldis Pukitis, Dr. Diana Riekstina (Pauls Stradins Clinical University Hospital, Riga, Lativia)
- Dr. Ecaterina Rinja, Dr. Sandru Vasile (Department of Gastroenterology, Clinical Emergency Hospital of Bucharest, Romania)
- Prof. Dr. Maria Lourdes Ruiz-Rebollo (Aparato Digestivo, Hospital Clínico Universitario de Valladolid, Spain)
- Prof. Robert Jaster, Dr. Julia Woitalla (Department of Medicine II, University Hospital Rostock)
- Prof. Dr. Steven A Johnson (Robert Bosch center, Stuttgart, Germany)
